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Nature 649 , 477486 (2025)

Among the most frequent adverse effects are: vomiting, nausea, diarrhea, hypoglycemia in case of use with oral diabetes medications other than sulfonylureas or insulin, gastritis, stomach pain, fatigue, constipation, dizziness, retinopathy

15 In the SURPASS-1 study, tirzepatide monotherapy at increasing doses of 5, 10, and 15 mg resulted in significant weight loss of 7, 7.8, and 9.5 kg, respectively, at week 40 in patients with T2DM, compared with a 0.7 kg decrease with placebo

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