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This is consistent with the idea that memories are not just consolidated during sleep but are also actively reorganized to help cognitive processes such as generalization (Stickgold and Walker, 2013) or creative thinking and problem solving (Lewis et al., 2018)

Endogenous peptides frequently evolved to coordinate multiple processes simultaneously

Upon treating mucinous lung adenocarcinoma with the EGFR inhibitor gefitinib, the EGFR ligand amphiregulin promotes the binding of IGF-IR to importin-1 and triggers nuclear localization of IGF-IR, which in turn prevents the induction of apoptosis by gefitinib [117]

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Fallon MT, Storey DJ, Krishan A, Weir CJ, Mitchell R, Fleetwood-Walker SM,