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Consistent with this, exendin-P5, which induces faster kinetics in G protein activation and cAMP production, exhibits higher cAMP efficacy than GLP-1 and exendin-4, as indicated by a greater pEC 50 /pIC 50 ratio when comparing cAMP and binding studies 13

123 ParazziniF.MaisV.CiprianiS.BusaccaM.VenturiniP.GISE (2009)

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A large N-terminal extracellular domain (ECD) captures the C-terminal portion of peptide ligands through a "catch and release" mechanism, while the ligand's N-terminal region inserts into the transmembrane domain (TMD) to activate the receptor

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