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Additionally, we employed various medications and biochemical data as proxies for disease severity, helping to mitigate the inherent limitations of using electronic health records

Hormonal changes often related to pregnancy or contraceptive use

It reduces appetite and caloric intake, leading to significant weight loss when combined with diet and exercise

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The NMNAT1 and NMNAT3 transgenic mouse strains used here were as previously described (Yahata et al, 2009), and the colony was maintained through breeding heterozygous males with wild-type females, with a subsequent Mendelian ratio of offspring to be used for experiments of 50% heterozygous transgenics, and 50% wild-type littermate controls