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The authors found that BPDB-based MOFs exhibited GSH concentration-dependent NO release (Figure 2G), and four molecules of NO can be released from each BPDB molecule provoked by two molecules of GSH (Figure 2H)

Proteomic analysis in animal models also showed the overexpression of plasma orosomucoid 2, and the sensitivity and specificity in using elevated orosomucoid 2 to discriminate cholangiocarcinoma cases from healthy controls were 92.9% (65 out of 70 cases) and 73.7% (350)

There is no question that dietary optimization and the use of better studied supplements like omega-3s or probiotics are likely to be more effective

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