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The receptor-independent passive access theory presented by Kastin and colleagues [88,89] challenges the classical dogma that BBB only allows its paracellular access of molecules that are smaller than 500 Da, while native gut-produced GLP-1 and GLP-1RA therapeutic agents are much larger than 3000 Da
used LNCaP and PC3 PCa cell lines
A recent study shows that if ferroptosis is suppressed, the production of ROS in mitochondria would be reduced, which can save the toxicity caused by inhibition of mitochondrial complex I (Li N
Damage to proteins ROS reacts with proteins and disrupts protein folding ( OH is the predominant ROS species that causes oxidative damage to proteins
Common investigations may include blood sugar and serum insulin levels
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