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The escalation typically started at 2 mg weekly for the first 4 weeks, then increased every four weeks in increments of 2 to 4 mg until the target research dose was reached

Contact your GP or NHS 111 if you experience: persistent vomiting that prevents you from keeping down fluids, signs of dehydration (dark urine, dizziness, extreme thirst), severe or bloody diarrhoea, or other concerning symptoms

First GLP-1s must be treated as a long-term structural factor, not a passing trend

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