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Several approaches evaluated the inhibition of TGF- signaling in glioma (www.clinicaltrials.gov) using antibodies, antisense oligonucleotides, ligand traps or TGF- receptor kinase inhibitors 29,45

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The action of the hydroxyl free radical on cardiolipin releases 4-hydroxynonenal (4-HNE) and on other mitochondrial lipids and mtDNA releases malondialdehyde (MDA), acrolein, and crotonaldehyde

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