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Backbone modifications include fatty-acid acylation that supports albumin binding and extends plasma half-life to approximately six days, which underpins the once-weekly subcutaneous dosing pattern used across the published clinical trials

The Rejuva platform focuses on developing next-generation adeno-associated virus (AAV)-based, locally delivered gene therapies for the treatment of T2D and obesity

Expect more to emerge over the next few years due to more use

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