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Bmal knockout (arrhythmic) mice display progressing prothrombotic state characterized by reduced prothrombin times, increased platelet count, a reduction in nitric oxide/thrombomodulin expression from endothelial cells ( Clock is also involved in the regulation of hemostasis

pH value and viscosity adjustment pH value adjustment: The pH value of the cream needs to be adjusted to an appropriate range (usually 5.5-7.0) to conform to the physiological environment of the skin and reduce irritation

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