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Important additional risks include diabetic retinopathy complications (particularly in patients with pre-existing retinopathy or rapid improvement in blood glucose), gallbladder disease (such as gallstones), and kidney problems related to dehydration from persistent vomiting or diarrhoea

But can they truly extend lifespan alone

If you are experiencing severe or persistent diarrhea at a given dose level, extending that dose period from 4 weeks to 6 or even 8 weeks before escalating is a legitimate strategy

Diabetes GLP-1s perform better but still leak demand: Diabetes-indicated GLP-1s show higher retention (24% at one year) and face fewer access hurdles due to broader coverage and disease framing, yet 76% of demand remains unmet

"[December 2025] was one of the darkest times of my life, and it was scary," Bunnie, a podcast host and author, said