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In STEP-3 (N=611), semaglutide combined with intensive behavioral therapy produced a mean 16.0% body weight reduction at 68 weeks, with GI side effects reported in 82.8% of the semaglutide group versus 63.6% on placebo [7]

However, hyperuricemic patients with varying degrees of ABCG2 dysfunction, categorized by genotypes of dysfunctional SNPs, exhibit hyperuricemia characterized by urate overproduction

For patients at the highest risk, such as those with diabetic autonomic neuropathy or on opioids, combining prolonged fasting with ultrasound-guided assessment offers a practical, evidence-based strategy