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In luminal breast cancer, ER/PR positivity is positively correlated with GPX4 expression, while m6A demethylation activates SLC7A11 by inhibiting the FGFR4/GSK-3 pathway, thereby increasing sensitivity to ferroptosis [85]

In addition to the activity of the two enzymes involved in GSH synthesis, the availability of the amino acid substrates for GSH synthesis determines the rate of GSH synthesis and the GSH concentration in cultured rat astrocytes (Dringen and Hamprecht 1998