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The accumulation of toxic protein fragments disrupts various cellular functions, including mitochondrial protein import (Yano et al., 2014), synaptic integrity (Peng et al., 2018), and transcriptional regulation (Figure 7B)

The finding established that the GSH redox cycle is the primary intracellular antioxidant defence system in endothelial cells against peroxide-mediated oxidative stress, and remains a foundational reference for endothelial oxidative stress research using GSH manipulation

Mol Cell Pharmacol

doi: 10.1093/toxsci/kfj017

Knowing the best ways to optimize glutathione levels in tissues and blood is important