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A pre-bed dose is timed to reinforce that natural nocturnal pulse, which is why the pre-bed slot is the one most consistently kept even in a once-daily schedule

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The role of autophagy and mitophagy in NDDs Autophagy and mitophagy are indispensable for neuronal survival, given the post-mitotic nature of neurons, their extraordinary metabolic demands, and their reliance on precise proteostasis and mitochondrial quality control

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Blackmon SH, Correa AM, Wynn B, Hofstetter WL, Martin LW, Mehran RJ, Rice DC, Swisher SG , Walsh GL, Roth JA, Vaporciyan AA