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Activating GLP-1R has been reported to enhance glycolysis in insulin-resistant neurons [61], ischemic rat hearts [62], and natural killer cells from obese individuals [63]

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Summary: Wegovy does not directly cause kidney stones, but its gastrointestinal side effects may lead to dehydration, which is a recognised risk factor for stone formation

Female mice are also more sensitized to CRH-induced ACTH production (71, 72), and show elevated AVP expression in the stress-responsive medial parvocellular dorsal division of the PVN (66, 70) ( Figure 2 )

YZ, RL, and SG drafted the manuscript