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Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

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These data support a role for IGF-I signaling in skeletal cell-cell interactions by stimulating RANKL/RANK and ephrin B2/EphB4 pathways in the cells (Figure 2)