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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

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(2021), which demonstrated significant activation of the TLR4/NF-B pathway in the endometrial tissue of PCOS patients ( 3.2 Exacerbation of insulin resistance Studies confirm that LPS and its induced inflammatory cytokines (e.g., TNF-) directly disrupt insulin signaling

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