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Central GLP-1R circuits engaged by long-acting agonists

Seek medical help if constipation lasts more than a few days or is accompanied by pain, vomiting, or bleeding, as these can indicate more serious digestive complications

Weight loss averages 11 to 15 percent of starting body weight by month 6

This method can often help to minimize side effects as it allows time for the body to adjust to the medication

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