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This structural feature contributes to orforglipron's selectivity for the GLP-1 receptor over other incretin receptors, a property that distinguishes it from multi-receptor agonists like tirzepatide and retatrutide

Other filings allege motility disorders that can present like an intestinal blockage, including ileus-type symptoms and other severe complications requiring hospitalization

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10.1007/s00204-009-0436-9 Arch

The top speed for each mouse was defined as the speed of the last successfully completed 5 minutes interval