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What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (consuming the methyl donor SAM) to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway

Therefore, a single-timepoint elevation of Bax or NF-B after PRP administration should be interpreted with caution, as it does not necessarily indicate net tissue loss

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Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier