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Maximum weight loss (20%+ body weight) Achieving 20 percent or greater weight loss consistently requires the higher dose levels of 10mg to 15mg weekly, maintained over nine months to a year or longer

A preclinical study found that TRZ-inducing weight loss regulates adipocytokines, including adiponectin and leptin, in obese mice (Samms et al

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The treatment should be part of a comprehensive weight management plan that includes a healthy diet and regular physical activity

Safety and tolerability issues were also similar across groups, suggesting that dose adjustment is not required in patients with hepatic impairment