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The expression of ATP-binding cassette subfamily B member 7 and mitochondrial oxidative phosphorylation enzymes were significantly downregulated in rats with left ventricular hypertrophy, while lipid metabolites, iron, ROS, and autophagy-associated proteins were upregulated in the cytoplasm and mitochondria

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These findings all illustrate that VDAC plays an important role in ferroptosis

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For example, medications like semaglutide and tirzepatide have demonstrated significant weight loss in people with obesity by helping control hunger and reduce calorie intake