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The tools we use to measure lean mass in clinical trials (DXA) likely overestimate the muscle component of LBM loss because they cannot distinguish liver and muscle substrate changes from actual contractile protein loss

Twenty-four hours after last injection, these T3-treated hypothyroid mice with normal serum T3 levels (MMI + T3-5d mice) were compared to the hypothyroid mice with serum T3 values decreased by approximately 60% (MMI mice) to minimize the effects of potential confounding factors (Supplementary Fig

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I used several words back that I am not proud of