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[1] In clinical studies, lactate shows promise as a treatment for inflammatory conditions including traumatic brain injury and as a means to deliver fuel to working muscles

The overexpression of metrnl induces the expression of SIRT3 by promoting the expression of transcriptional activator PGC-1, increasing the expression level of UCP1 and the activation of AMPK in PA-treated RTECs to accelerate mitochondrial autophagy, maintain mitochondrial homeostasis, and alleviate lipid accumulation (a thermogenic factor) (Zhou et al., 2023)

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doi:10.1007/978-1-60761-756-3_18

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