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The main differences across comparison categories are: Mechanism of Action: advantage goes to NAD+

pH is maintained by both the lungs (by retaining or removing carbon dioxide) and kidneys (by secreting acid and absorbing bicarbonate [HCO3-] from the filtrate in the renal tubules) (Al-Awqati 2012

Copper deficiency impairs mitochondrial biogenesis (PGC-1) and disrupts COX assembly (via COX17, SCO1, and SCO2), resulting in bioenergetic failure due to ATP deficiency

In fact, reduced levels of glutathione have been linked to both Parkinsons disease and neuronal damage following stroke

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