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Monoacidic inhibitors of the Kelch-like ECH-Associated Protein 1: nuclear factor Erythroid 2-related factor 2 (KEAP1:NRF2) proteinprotein interaction with high cell potency identified by fragment-based discovery

shows that sirtuin 3 can prevent anesthesia/surgery-induced cognitive decline in aged mice through inhibiting mitochondrial damage and hippocampal neuroinflammation caused by calcium overload [23]

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We further demonstrated that CoQ 10 H 2 inhibited transcriptional activity of the transcription factor AP-1 and that of C-FOS, a component of AP-1, and that CoQ 10 H 2 inhibited the ability of AP-1 to bind to the PDE4 gene promoter (Fig

Vicencio JM, Ortiz C, Criollo A, Jones A, Kepp O, Galluzzi L, et al