Therapeutic strategies targeting the MGB axis, including prebiotics, synbiotics, and fecal microbiota transplantation, are not universally applicable
Negative evidence: A study in Indonesian individuals showed that supplementation with glutathione combined with vitamin C, alpha-lipoic acid, and zinc did not significantly lighten skin compared to placebo (Sitohang et al., J Clin Aesthet Dermatol, 2021) [63]
Group means were compared by one-way ANOVA, followed by a Students unpaired t -test
These results highlight the need for clinical trials to determine effective dosing, treatment duration, combination strategies, and long-term safety
It helps remove damaged proteins, neutralizes lipid peroxidation products, and assists in eliminating cellular debris