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One of the primary effects of consuming edible cannabis is an increased appetite, often referred to as the munchies. This is due to the interaction between the active compounds in cannabis, such as tetrahydrocannabinol (THC), and the endocannabinoid system, which plays a role in regulating appetite and metabolism

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We excluded patients with bariatric surgery history and required weight measurements during baseline (90 days pre-treatment), the first year post-treatment (year 1), and the second year post-treatment (year 2), yielding 34,143 semaglutide-treated and 16,034 tirzepatide-treated patients ( Figure S1 )