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Enterohepatic circulation further influences LT4 metabolism, with conjugation via glucuronidation and sulfation in the liver, secretion into bile, and partial reabsorption by the intestinal flora (Eghtedari And Correa 2023)

i , Conditioned Taste Avoidance (CTA) in lean wildtype and Vglut2-GLP-1R KO mice 24 h after single s.c

Taken together, these findings indicate that diabetes particularly compromises shortterm avoidancerelated memory, and that Retatrutide may confer limited but detectable protection against this early deficit without producing a clearly superior longterm retention profile across groups

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This represents an opportunity to reduce opioid prescribing and facilitate tapering in appropriate patients