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12,19-21 It is also possible that migraine-associated and nonmigraine CVS are two entirely different disorders with different pathophysiologies

Zhang, A

This occurs primarily in the form of GSH-dependent glutaredoxin enzymes, which use GSH to reduce protein disulfides [67], and GSH-dependent glutathione oxidase and peroxidase enzymes that catalyze the reduction of O 2 and H 2 O 2 by GSH [68,69]

Concurrently, inflamed adipose tissue secretes elevated free fatty acids, pro-inflammatory cytokines, and adipokines that exacerbate hepatic insulin resistance, lipotoxicity, and fibrogenesis [2]