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Our results confirm those previously proposed by others [33] that the higher Rho activity is, the greater the polymerization of F-actin and the cytoplasmic retention of p53, while in contrast, the potent and rapid inhibition of actin polymerization by cytochalasin D promoted rapid nuclear translocation of p53, correlated with the availability of cytoplasmic G-actin (Fig

Any of these signs warrant prompt medical evaluation