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AI is even being applied to novel drug target identification, using innovative algorithms to predict new therapeutic avenues ( FIGURE 5 6 Translational biomarkers & diagnostic platforms (blood, urine, imaging) Metabolomic signatures face significant challenges due to confounding by extrinsic factors (diet, medications including SGLT2i/GLP-1RAs, comorbidities) and the predominance of cross-sectional studies with modest sample sizes, limiting causal inference and generalizability