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Symptoms unresponsive to typical methylation or neurotransmitter-based therapies

5 Challenges and future directions in microbiota-based interventions for hypothyroidism Although microbiota-targeted strategies present a promising adjunct in the management of hypothyroidism, several critical challenges must be addressed to fully realize their therapeutic potential (Figure 5)

Therefore, if there is another unknown GST that has higher activity than the identified GST s, the unknown GST could have proliferated instead of the identified ones

Further longitudinal analyses in initially non-depressed subjects are needed to properly disentangle these two mutually non-exclusive scenarios

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