period changes on semaglutide and Your Period: What Science Says Can Semaglutide Cause irregular Periods

Phase 2 Trial Results The Phase 2 TRIUMPH trial published data showing: Average weight loss of approximately 17.5% at 24 weeks (highest dose group) Projected weight loss exceeding 24% at 48 weeks based on trajectory Dose-dependent weight loss, higher doses produced stronger outcomes Blood sugar improvements consistent with the GLP-1 mechanism For context, tirzepatide produced approximately 2022% weight loss over 72 weeks in SURMOUNT

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The 4 studies (n=481 pregnancies) comprised women with type 1 diabetes (n=366), women with type 2 diabetes (n=84), women diagnosed with overt diabetes in pregnancy (n=12) and women with insulin-requiring GDM (n=19)

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They reduce the release of cytokines like IL-1, IL-6, and TNF, upregulate the anti-inflammatory cytokine TGF-, and downregulate the expression of disease-associated microglial (DAM) genes, ultimately enhancing A clearance [74]