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This does not mean every elevated SAH result proves toxicity. It means toxic and inflammatory burden should be considered when methylation support fails, symptoms worsen with methyl donors, glutathione demand is high, or the patient has mold, chemical, gastrointestinal, renal or mitochondrial clues

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It occurs in approximately 1 in 20,000-30,000 live births ( 1.1 Genetic background Approximately 60% of patients with PWS have a deletion on the paternal chromosome 15q (del15q), located between common breakpoints (BPs two proximal sites known as BP1 and BP2, and one distal site named BP3)

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