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MacdonaldSBosioEShapiroNIBalmerLBurrowsSHibbsMet al

Compared to the placebo in these studies, melatonin was shown to significantly improve sleep onset latency and total sleep time in adults with delayed sleep phase disorder and in children/adolescents with a variety of neurodevelopmental disorders

It is worth noting that the bond dissociation enthalpy is as high as 305440 kJmol 1 , which is much higher than that of antibody conjugation systems based on non-covalent affinity interactions [120]

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Sleep and circadian restoration Researchers specifically targeting sleep improvement might emphasize bedtime administration and potentially start with lower doses to assess individual sensitivity to melatonin-related effects