bmi requirement for glp 1 Qualifications Semaglutide and Tirzepatide GLP-1 RAs: Baseline BMI and

12 , e34 (2010)

[1] [2] Using improperly stored GLP-1 medication may result in inadequate glycemic control for patients with type 2 diabetes, potentially leading to hyperglycemia

This vasodilatory effect requires special consideration for patients with hypovolemic POTS (caused by chronically low blood volume)

In the SURPASS-2 diabetes trial, an open-label 40-week study randomised 1,879 patients with type 2 diabetes to tirzepatide 5, 10, or 15 mg or to semaglutide 1 mg

While GLP-1 could potentially have a dual therapeutic role, researchers faced an enormous challenge: the plasma half-life of GLP-1 was only one to two minutes