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Because NNMT intersects NAD salvage, pairing with NMN/NR is a common experimental strategy to test additive or synergistic effects on cellular NAD and metabolic endpoints

A recent study also showed that infant vitamin B-12 supplementation was associated with improved gross motor function and less frequent gastrointestinal regurgitation compared with placebo (42)

95% CI 9.42 to 7.88

However, understanding when high B12 levels may become problematic helps ensure safe, evidence-based supplementation under appropriate medical supervision

When NNMT activity is reduced, cells can more efficiently utilize nicotinamide adenine dinucleotide (NAD+), leading to enhanced mitochondrial function and improved metabolic flexibility