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The flow diagram of the literature search process is presented in online Supplementary Fig

Numerous other studies on the collagenase produced by Clostridium histolyticum have revealed that it is healthy, noninvasive, and safe in treating several pathological conditions 53

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This combination shows promise for treating conditions like the ones mentioned earlier: particular benefits include providing relief from inflammatory bowel diseases, support for joint injuries of all kinds, and potential treatment solutions for central nervous system disorders