Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in sepn1-related myopathy
(Clemmitt, 2024)
But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness Heart palpitations and shortness of breath Pale skin A smooth tongue Constipation, diarrhoea, loss of appetite, or gas Nerve problems like numbness or tingling, muscle weakness, and problems walking ( late signs of low B12/folate) Vision loss Mental problems like depression, memory loss, or behavioural changes Vitamin B12 is naturally present in foods of animal origin, including: In addition, nutritional yeasts contain readily available sources of vitamin B12 that have high bioavailability
10.1038/s41380-024-02848-3 38 LozanoA
You will have to figure out what your body does best on, but in general, I recommend using 5,000mcg per day in sublingual form as long as you are not extremely sensitive to supplements and/or medications