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All authors read and approved the final manuscript

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(56) employed ajoene at 3 g/ml extract concentrations to boost macrophage antimycobacterial activity

Thus, it became an effective target for covalent BTK inhibitors such as ibrutinib ( The most frequent cytogenetic mutation in CLL is the 13q deletion (del[13q]), found in around 50% of CLL cases ( One of the biggest challenges in treating CLL is the development of resistance to BTK and BCL-2 inhibitors