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The metal chelating effect of sinapic acid, a phenylpropanoid compound found in various herbs and high-bran cereals has been reported to possess a protective role against arsenic induced toxicity in rats [190]

It is reported that aldehyde-reactive alkoxyamines can capture the AP sites, one of the most common DNA lesions, and inhibit apurinic/apyrimidinic endonuclease 1(APE1)-mediated base excision repair (BER), leading to cell death

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RA patients with the A1ATD PiMZ phenotype have been found to exhibit van increased prevalence and higher titers of anticitrullinated peptide autoantibodies (ACPA), indicating a distinct subset with greater disease severity (92)