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The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer

The second might spend the same nominal amount but get half the results, effectively doubling their real cost

A major translational hurdle is the development of agents that can effectively cross the BBB to reach central auditory structures

Reviewed submitted version of manuscript: both authors