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Combination with GLP-1 RAs: Research has focused on the potential for dual-pathway modulation (amylin + GLP-1) to enhance weight and metabolic outcomes compared with monotherapy

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Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden

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