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The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

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Pre-mixed vials lock the ratio they cannot be used during the staged titration described above without overdosing one component or underdosing the other

This difference in research maturity may influence how clinicians approach prescribing discussions and what they can reference when establishing protocols

Unger, "GCG is the key factor in the development of diabetes," Diabetologia, vol