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Instead, FAM makes value assessments using Generalized Risk-Adjusted Cost-Effectiveness (GRACE), which recognizes that sicker patients value health gains more than healthier patients

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Graphical Abstract 1 Introduction Neurological conditions, including central nervous system (CNS) disorders, have emerged as the leading cause of illness and disability worldwide, affecting more than 3 billion individuals more than one-third of the global population based on a study in 2021 (GBD, 2021 Nervous System Disorders Collaborators, 2024)

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