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This, in turn, may result in decreased infiltration of inflammatory cells into lung tissues in murine models, alongside lower levels of tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) production, further mitigating tissue damage

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Bicuculline is a competitive antagonist of GABAARs primarily on the ionotropic GABAARs, ligand-gated ion channels, and the passing of chloride ions across the cell membrane [230]

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