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To determine if APAP ingestion resulted in increased ROS in the Drosophila fat body, we stained APAP-treated and control early third-instar larvae with HydroCy3, a ROS sensitive dye that fluoresces in the presence of superoxide radicals 29

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Nature 454:232235 Jagadeeswaran R, Lenny H, Vazquez B et al (2017) The abnormal Presence of mitochondria in circulating red blood cells cause an increased oxygen consumption rate, ROS generation and hemolysis in patients with sickle cell disease

Additionally, the remodeling of the extracellular matrix (ECM) facilitated by ROS enhances tumor invasion, allowing melanoma cells to disseminate more effectively 56