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A high titer of RF classifies the patient as having seropositive RA, which is characteristically associated with a more aggressive disease course, greater radiographic joint destruction, and a higher likelihood of extraarticular manifestations, such as the subcutaneous nodule seen on Helen's forearm (Shmerling & Greisen, 2025)

Testosterone levels naturally decline as you age

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These studies assess parameters like bone density, nerve regeneration markers, and inflammatory cell infiltration

doi: 10.1093/ajcn.81.2.508